翻訳と辞書 Words near each other ・ Cyclic corrosion testing ・ Cyclic Defrost ・ Cyclic delay diversity ・ Cyclic di-AMP ・ Cyclic di-GMP ・ Cyclic di-GMP-I riboswitch ・ Cyclic di-GMP-II riboswitch ・ Cyclic enzyme system ・ Cyclic executive ・ Cyclic flower ・ Cyclic form ・ Cyclic GMP-AMP synthase ・ Cyclic graph ・ Cyclic group ・ Cyclic guanosine monophosphate ・ Cyclic guanosine monophosphate–adenosine monophosphate ・ Cyclic history ・ Cyclic homology ・ Cyclic ketogenic diet ・ Cyclic mass ・ Cyclic microcellular foaming ・ Cyclic model ・ Cyclic module ・ Cyclic negation ・ Cyclic neutropenia ・ Cyclic nucleotide ・ Cyclic nucleotide gated channel beta 3 ・ Cyclic nucleotide phosphodiesterase ・ Cyclic nucleotide-binding domain ・ Cyclic nucleotide-gated channel alpha 1 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Cyclic guanosine monophosphate–adenosine monophosphate ： ウィキペディア英語版 Cyclic guanosine monophosphate–adenosine monophosphate Cyclic guanosine monophosphate–adenosine monophosphate (cyclic GMP-AMP, cGAMP) is the first cyclic di-nucleotide found in metazoa. In mammalian cells, cGAMP is synthesized by cyclic GMP-AMP synthase (cGAS) from ATP and GTP upon cytosolic DNA stimulation. cGAMP produced by cGAS contains mixed phosphodiester linkages, with one between 2'-OH of GMP and 5'-phosphate of AMP and the other between 3'-OH of AMP and 5'-phosphate of GMP. This molecule, referred to as 2′3′-cGAMP (cyclic ()), functions as an endogenous second messenger inducing STING-dependent type I interferon response.〔〔 cGAMP has also been shown to be an effective adjuvant that boosts the production of antigen-specific antibodies and T cell responses in mice. cGAMP exercises antiviral functions in the cell where it is produced, but can also cross cell membranes by passive diffusion to exert effects on neighboring cells.〔 It may even be packaged into lentivirus (such as HIV-1), poxvirus and herpes virus, and under cell culture conditions has been found to transmit an antiviral signal to the cells infected with these viruses; however, there is reason to think that at least HIV is capable of evading this mechanism by some means. == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cyclic guanosine monophosphate–adenosine monophosphate」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.